Publications, Posters, <br> and Other Information
Publications, Posters,
and Other Information
Filters
Filters
Areas of Interest
Techniques
Document Type
Date
Show (46)
Cancel

Publications and Posters

Molecular profiling of glioblastoma patient-derived single cells using combined MALDI-MSI and MALDI-IHC
February 11, 2025  •  Krestensen, K. K., Hendriks, T. F. E., Grgic, A., Derweduwe, M., De Smet, F., Heeren, R. M. A., & Cuypers, E. (2025).  Analytical Chemistry.
Exploring the Aβ plaque microenvironment in Alzheimer’s disease model mice by multimodal lipid-protein-histology imaging on a benchtop mass spectrometer
February 5, 2025  •  Müller, E., Enzlein, T., Niemeyer, D., von Ammon, L., Stumpo, K., Biber, K., Klein, C., & Hopf, C. (2025). Pharmaceuticals (Basel, Switzerland), 18(2), 252.
Sequential MALDI-HiPLEX-IHC and Untargeted Spatial Proteomics Mass Spectrometry Imaging to Detect Proteomic Alterations Associated with Tumour Infiltrating Lymphocytes
January 3, 2025  •  Bindi, G., Monza, N., de Oliveira, G. S., Denti, V., Fatahian, F., Seyed-Golestan, S.-M. J., L’Imperio, V., Pagni, F., & Smith, A. (2025). In Journal ...
How can MSI enhance our understanding of ASO distribution?
January 1, 2025  •  van der Vloet, L., Hilaire, P. B. S., Bouillod, C., Isin, E. M., Heeren, R. M. A., & Vandenbosch, M. (2025).   In Drug Discovery Today ...
Multiplexed and Multiomic Mass Spectrometry Imaging of MALDI-IHC Photocleavable Mass Tag Tissue Probes, N-Glycomics, and the Extracellular Matrisome from FFPE Tissue Sections
December 24, 2024  •  Taylor, H. B., Dunne, J. B., Lim, M. J., Yagnik, G., Rothschild, K. J., Mehta, A., Drake, R. R., & Angel, P. M. (2024). In Methods in Molecular Biology (pp. 305–332). Springer US. • Multiomic and Multimodal techniques
Exploring the Aβ Plaque Microenvironment in Alzheimer’s Disease Mice by Multimodal Lipid-Protein-Histology Imaging on a Benchtop Mass Spectrometer
December 7, 2024  •  Müller, E., Enzlein, T., Niemeyer, D., von Ammon, L., Stumpo, K., Biber, K., Klein, C., & Hopf, C. (2024). Cold Spring Harbor Laboratory. • Multiomic and Multimodal techniques
MALDI-IHC high-plex protein biomarker imaging for fast, non-iterative identification of lung carcinoma subtype
November 13, 2024  •  AACR 2024 • Catherine A. Kita, Leonardo G. Dettori, Kristina Schwamborn, Gargey Yagnik, Kenneth J. Rothschild, Mark J. Lim
Single Cell MALDI-MSI Analysis of Lipids and Proteins within a Replicative Senescence Fibroblast Model
October 30, 2024  •  Sekera, E. R., Rosas, L., Holbrook, J. H., Angeles-Lopez, Q. D., Khaliullin, T., Rojas, M., Mora, A. L., & Hummon, A. B. (2024). In Journal of the American Society for Mass Spectrometry. American Chemical Society (ACS). • Multiomic, Lipids, Proteins, Single-Cell
Targeting ferroptosis with the lipoxygenase inhibitor PTC-041 as a therapeutic strategy for the treatment of Parkinson’s disease
September 18, 2024  •  Minnella, A., McCusker, K. P., Amagata, A., Trias, B., Weetall, M., Latham, J. C., O’Neill, S., Wyse, R. K., Klein, M. B., & Trimmer, J. K. (2024). In H. Nakano (Ed.), PLOS ONE (Vol. 19, Issue 9, p. e0309893). Public Library of Science (PLoS). • Drug study incorporating MALDI-IHC, Pharma
MALDI Imaging applications on a new benchtop MALDI axial TOF instrument
September 9, 2024  •  IMSIS 2024 • Oetjen, Janina, Wendik, Björn, Henkel, Corinna, Kiss, Andras, Nordmann, Christoph, Böhm, Sebastian, Haase, Andreas, Kobarg, Jan Hendrik, Boskamp, Tobias, Schweiger Hufnagel, Ulrike, ...
Mass spectrometry imaging for spatially resolved multi-omics molecular mapping
July 17, 2024  •  Zhang, H., Lu, K.H., Ebbini, M. et al. npj Imaging 2, 20 (2024). • Multiomic, Review Article
Gel-assisted mass spectrometry imaging enables sub-micrometer spatial lipidomics
June 12, 2024  •  Chan, Y. H., Pathmasiri, K. C., Pierre-Jacques, D., Hibbard, M. C., Tao, N., Fischer, J. L., Yang, E., Cologna, S. M., & Gao, R. (2024). In Nature Communications (Vol. 15, Issue 1). Springer Science and Business Media LLC. • Multiomic, GAMSI, Expansion-Microscopy, Lipids, Proteins
Multimodal Omics Imaging of Human Brain Using MALDI HiPLEX-IHC
June 2, 2024  •  ASMS 2024 • Yumiko Toyama, Takashi Nirasawa, Shigeo Murayama, Yuko Saito, Maho Morishima, Masaya Ikegawa
Multiplex and multiomic MS imaging of drugs, metabolites, and immunolabeled pathogenic protein markers within a single tissue section
June 2, 2024  •  ASMS 2024 • Prem Shankar; Reina N Paez; David Beaver; Bandana Bera; Brendan Prideaux
Combining Drug and Targeted Protein Imaging to Uncover Molecular Changes Associated with Cancer Treatment
June 2, 2024  •  ASMS 2024 • Erin H. Seeley, Catherine A. Kita, Gargey Yagnik, Kenneth J. Rothschild, Mark J. Lim, Rahul A. Sheth
MALDI-ICC and SpaceM on PBMCs Spiked with Cancer Cells for Highly Multiplexed, Multiomic and Multimodal Single-Cell Profiling
June 2, 2024  •  ASMS 2024 • Ziying Liu, Gargey Yagnik, Sharath K. Menon, Shawn Owens, Leonardo G. Dettori, Philip Carvalho, Kenneth J. Rothschild, Theodore Alexandrov, and Mark J. ...
Cyclic MALDI-IHC for Successive High-plex and Multimodal Imaging of Tissues and Tissue Microarrays
June 2, 2024  •  ASMS 2024 • Leonardo G. Dettori, Gargey Yagnik, Philip Carvalho, Mark J. Lim and Kenneth J. Rothschild
Multimodal Mass Spectrometry Imaging of an Osteosarcoma Multicellular Tumour Spheroid Model to Investigate Drug-Induced Response
May 29, 2024  •  Pearce, S.M.; Cross, N.A.; Smith, D.P.; Clench, M.R.; Flint, L.E.; Hamm, G.; Goodwin, R.; Langridge, J.I.; Claude, E.; Cole, L.M. Metabolites 2024, 14, 315. • Drug study, Multiomic, Multimodal, Tumor Spheroids
Real-time glioblastoma tumor microenvironment assessment by SpiderMass for improved patient management
April 16, 2024  •  Zirem, Y., Ledoux, L., Roussel, L., Maurage, C. A., Tirilly, P., Le Rhun, É., Meresse, B., Yagnik, G., Lim, M. J., Rothschild, K. J., Duhamel, M., Salzet, M., & Fournier, I. (2024). In Cell Reports Medicine (Vol. 5, Issue 4, p. 101482). Elsevier BV. • MALDI-IHC was orthogonal verification tech
Abstract 7088: MALDI-IHC high-plex protein biomarker imaging for fast, non-iterative identification of lung carcinoma subtypes
March 15, 2024  •  Kita, C. A., Schwamborn, K., Yagnik, G., Rothschild, K. J., & Lim, M. J. (2024). In Cancer Research (Vol. 84, Issue 6_Supplement, pp. 7088–7088). American Association for Cancer Research (AACR). • Clinical Translation, Published Abstract
Molecular analysis of the extracellular microenvironment: from form to function
March 1, 2024  •  Macdonald, J. K., Mehta, A. S., Drake, R. R., & Angel, P. M. (2024). In FEBS Letters (Vol. 598, Issue 6, pp. 602–620). Wiley. • Multiomics, Tools to be used for studying tumor ECM inc. MALDI-IHC
Advancing rare cancer research by MALDI mass spectrometry imaging: Applications, challenges, and future perspectives in sarcoma
February 25, 2024  •  Stillger, M. N., Li, M. J., Hönscheid, P., von Neubeck, C., & Föll, M. C. (2024). In PROTEOMICS (Vol. 24, Issues 12–13). Wiley. • Multiomic and Multimodal techniques
Quantitative mass spectrometry imaging: therapeutics & biomolecules
January 22, 2024  •  Holbrook, J. H., Kemper, G. E., & Hummon, A. B. (2024). In Chemical Communications (Vol. 60, Issue 16, pp. 2137–2151). Royal Society of Chemistry (RSC). • Review Article
Technology Spotlight: Advances in Proteomic Technologies and Their Applications in Hematology
January 17, 2024  •  Mangalaparthi, K. K., & Pandey, A. (2024). In The Hematologist (Vol. 21, Issue 1). American Society of Hematology. • Review Article
Utilizing multimodal mass spectrometry imaging for profiling immune cell composition and N-glycosylation across colorectal carcinoma disease progression
January 10, 2024  •  Young, L. E. A., Nietert, P. J., Stubler, R., Kittrell, C. G., Grimsley, G., Lewin, D. N., Mehta, A. S., Hajar, C., Wang, K., O’Quinn, E. C., Angel, P. M., Wallace, K., & Drake, R. R. (2024). In Frontiers in Pharmacology (Vol. 14). Frontiers Media SA. • Multiomic, Multimodal
A novel 3D imaging method to establish baseline amyloid‐beta plaque load and analyze compound efficacy in pre‐clinical Alzheimer’s disease animal models
December 24, 2023  •  Ferron, G., Linehan, S. T., Ragan, T., Elk, K. J., Garceau, D., & Sasner, M. (2023). In Alzheimer’s & Dementia (Vol. 19, Issue S10). Wiley. • Published Abstract
The journey towards clinical adoption of MALDI-MS-based imaging proteomics: from current challenges to future expectations
December 23, 2023  •  Piga, I., Magni, F., & Smith, A. (2024). In FEBS Letters (Vol. 598, Issue 6, pp. 621–634). Wiley. • Clinical Translation, Review Article
Deep MALDI-MS Spatial ‘Omics guided by Quantum Cascade Laser Mid-infrared Imaging Microscopy
December 14, 2023  •  Gruber, L., Schmidt, S., Enzlein, T., Vo, H. G., Cairns, J. L., Ucal, Y., Keller, F., Abu Sammour, D., Rudolf, R., Eckhardt, M., Iakab, S. A., Bindila, L., & Hopf, C. (2023). Cold Spring Harbor Laboratory. • Multiomic and Multimodal techniques
Lipidomic Phenotyping Of Human Small Intestinal Organoids Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging
December 7, 2023  •  Duivenvoorden, A. A. M., Claes, B. S. R., van der Vloet, L., Lubbers, T., Glunde, K., Olde Damink, S. W. M., Heeren, R. M. A., & Lenaerts, K. (2023). In Analytical Chemistry (Vol. 95, Issue 50, pp. 18443–18450). American Chemical Society (ACS). • Multiomic, Organoids, Lipids, Proteins
A Guide to MALDI Imaging Mass Spectrometry for Tissues
October 25, 2023  •  Jessica L. Moore, Georgia Charkoftaki. Journal of Proteome Research 2023, 22 (11) , 3401-3417. • Review Article
Combination of Multimodal Single Cell Imaging Methods with Multiplexed Enzyme-based MALDI-Mass Spectrometry Imaging for Translational Studies
October 23, 2023  •  IMSIS 2023 • Jaclyn B. Dunne, Jake Griner, Martin Romeo, Carsten Krieg, Mark Lim, Gargey Yagnik Anand S. Mehta, Richard R. Drake, Peggi M. Angel
Evaluation of antibody-based single cell type imaging techniques coupled to multiplexed imaging of N-glycans and collagen peptides by matrix-assisted laser desorption/ionization mass spectrometry imaging
October 16, 2023  •  Dunne, J., Griner, J., Romeo, M., Macdonald, J., Krieg, C., Lim, M., Yagnik, G., Rothschild, K. J., Drake, R. R., Mehta, A. S., & Angel, P. M. (2023). In Analytical and Bioanalytical Chemistry (Vol. 415, Issue 28, pp. 7011–7024). Springer Science and Business Media LLC. • Multiomic, Multimodal techniques
Towards Single-Cell MALDI HiPLEX-IHC: Multiplexed, Multiomic and Multimodal Imaging of Targeted Intact Proteins and Untargeted Metabolites
September 17, 2023  •  HUPO 2023 • Mark Lim, Gargey Yagnik, Zhi Wan, Jonathan Bell, Joshua Fischer, Ethan Yang, Katherine A. Stumpo, Kenneth J. Rothschild
MALDI HiPLEX-IHC Imaging of FFPE Human Kidney Tissue at 5 µm utilizing microGRID on timsTOF fleX MALDI-2
June 4, 2023  •  ASMS 2023 • Connor West, Joshua Fischer, Corrina Henkel, Sumankalai Ramachandran, Azad Eshghi, Gargey Yagnik, Mark Lim
Gel-assisted mass spectrometry imaging
June 3, 2023  •  Chan, Y. H., Pathmasiri, K. C., Pierre-Jacques, D., Cologna, S. M., & Gao, R. (2023). Cold Spring Harbor Laboratory. • Multiomic and Multimodal techniques
MALDI HiPLEX-IHC: multiomic and multimodal imaging of targeted intact proteins in tissues
May 1, 2023  •  Lim, M. J., Yagnik, G., Henkel, C., Frost, S. F., Bien, T., & Rothschild, K. J. (2023). In Frontiers in Chemistry (Vol. 11). Frontiers Media SA. • Multiomic and Multimodal techniques
MALDI-IHC-Guided In-Depth Spatial Proteomics: Targeted and Untargeted MSI Combined
January 13, 2023  •  Claes, B. S. R., Krestensen, K. K., Yagnik, G., Grgic, A., Kuik, C., Lim, M. J., Rothschild, K. J., Vandenbosch, M., & Heeren, R. M. A. (2023). In Analytical Chemistry (Vol. 95, Issue 4, pp. 2329–2338). American Chemical Society (ACS). • Multimodal, proteins, lipids
MALDI-IHC-Guided In-Depth Spatial Proteomics
January 1, 2023  •  B.S.R. Claes, K. K. Krestensen, G. Yagnik, A Grgic, C. Kuik, M.J. Lim , K.J. Rothschild, M. Vandenbosch, R.M.A. Heeren
Mass spectrometry imaging in gynecological cancers: the best is yet to come
December 19, 2022  •  Pietkiewicz, D., Plewa, S., Zaborowski, M., Garrett, T. J., Matuszewska, E., Kokot, Z. J., & Matysiak, J. (2022). In Cancer Cell International (Vol. 22, Issue 1). Springer Science and Business Media LLC. • Multiomic and Multimodal techniques
MALDI HiPLEX-IHC: Highly Multiplex & Multiomic Tissue Imaging with Photocleavable Mass-Tagged Probes
June 5, 2022  •  ASMS 2022 • Gargey B. Yagnik; Ziying Liu; Zhi Wan; Kenneth J. Rothschild, Mark J. Lim
Highly Multiplexed Immunohistochemical MALDI-MS Imaging of Biomarkers in Tissues
February 25, 2021  •  Yagnik, G., Liu, Z., Rothschild, K. J., & Lim, M. J. (2021). In Journal of the American Society for Mass Spectrometry (Vol. 32, Issue 4, pp. 977–988). American Chemical Society (ACS). • MALDI-IHC overview
Proteome-wide drug screening using mass spectrometric imaging of bead-arrays
May 19, 2016  •  Zhou Y, Liu Z, Rothschild KJ, Lim MJ. Sci Rep. 2016 May 19;6:26125. doi: 10.1038/srep26125. PMID:27194112 Free PMC Article
Photochemical control of the infectivity of adenoviral vectors using a novel photocleavable biotinylation reagent
May 9, 2002  •  Mark W Pandori, David A Hobson, Jerzy Olejnik, Edyta Krzymanska-Olejnik, Kenneth J Rothschild, Abraham A Palmer, Tamara J Phillips, Takeshi Sano. Chem Biol 2002 May;9(5):567-73. doi: 10.1016/s1074-5521(02)00135-7.
Photocleavable peptide-DNA conjugates: synthesis and applications to DNA analysis using MALDI-MS
December 1, 1999  •  J Olejnik, H C Lüdemann, E Krzymanska-Olejnik, S Berkenkamp, F Hillenkamp, and K J Rothschild. Nucleic Acids Res. 1999 Dec 1; 27(23): 4626–4631. doi: 10.1093/nar/27.23.4626
Photocleavable aminotag phosphoramidites for 5′-termini DNA/RNA labeling
August 1, 1998  •  J Olejnik, E Krzymanska-Olejnik, and K J Rothschild. Nucleic Acids Res. 1998 Aug 1; 26(15): 3572–3576. doi: 10.1093/nar/26.15.3572
Photocleavable biotin derivatives: a versatile approach for the isolation of biomolecules
August 1, 1995  •  J Olejnik, S Sonar, E Krzymañska-Olejnik, and K J Rothschild. Proc Natl Acad Sci U S A. 1995 Aug 1; 92(16): 7590–7594. doi: 10.1073/pnas.92.16.7590