Publications - AmberGen

Publications and Posters

Exploring the Aβ plaque microenvironment in Alzheimer’s disease model mice by multimodal lipid-protein-histology imaging on a benchtop mass spectrometer

February 5, 2025 • Müller, E., Enzlein, T., Niemeyer, D., von Ammon, L., Stumpo, K., Biber, K., Klein, C., & Hopf, C. (2025). Pharmaceuticals (Basel, Switzerland), 18(2), 252.

Multiplexed and Multiomic Mass Spectrometry Imaging of MALDI-IHC Photocleavable Mass Tag Tissue Probes, N-Glycomics, and the Extracellular Matrisome from FFPE Tissue Sections

December 24, 2024 • Taylor, H. B., Dunne, J. B., Lim, M. J., Yagnik, G., Rothschild, K. J., Mehta, A., Drake, R. R., & Angel, P. M. (2024). In Methods in Molecular Biology (pp. 305–332). Springer US. • Multiomic and Multimodal techniques

Exploring the Aβ Plaque Microenvironment in Alzheimer’s Disease Mice by Multimodal Lipid-Protein-Histology Imaging on a Benchtop Mass Spectrometer

December 7, 2024 • Müller, E., Enzlein, T., Niemeyer, D., von Ammon, L., Stumpo, K., Biber, K., Klein, C., & Hopf, C. (2024). Cold Spring Harbor Laboratory. • Multiomic and Multimodal techniques

MALDI-IHC high-plex protein biomarker imaging for fast, non-iterative identification of lung carcinoma subtype

November 13, 2024 • AACR 2024 • Catherine A. Kita, Leonardo G. Dettori, Kristina Schwamborn, Gargey Yagnik, Kenneth J. Rothschild, Mark J. Lim

Single Cell MALDI-MSI Analysis of Lipids and Proteins within a Replicative Senescence Fibroblast Model

October 30, 2024 • Sekera, E. R., Rosas, L., Holbrook, J. H., Angeles-Lopez, Q. D., Khaliullin, T., Rojas, M., Mora, A. L., & Hummon, A. B. (2024). In Journal of the American Society for Mass Spectrometry. American Chemical Society (ACS). • Multiomic, Lipids, Proteins, Single-Cell

Targeting ferroptosis with the lipoxygenase inhibitor PTC-041 as a therapeutic strategy for the treatment of Parkinson’s disease

September 18, 2024 • Minnella, A., McCusker, K. P., Amagata, A., Trias, B., Weetall, M., Latham, J. C., O’Neill, S., Wyse, R. K., Klein, M. B., & Trimmer, J. K. (2024). In H. Nakano (Ed.), PLOS ONE (Vol. 19, Issue 9, p. e0309893). Public Library of Science (PLoS). • Drug study incorporating MALDI-IHC, Pharma

Multimodal Omics Imaging of Human Brain Using MALDI HiPLEX-IHC

June 2, 2024 • ASMS 2024 • Yumiko Toyama, Takashi Nirasawa, Shigeo Murayama, Yuko Saito, Maho Morishima, Masaya Ikegawa

Cyclic MALDI-IHC for Successive High-plex and Multimodal Imaging of Tissues and Tissue Microarrays

June 2, 2024 • ASMS 2024 • Leonardo G. Dettori, Gargey Yagnik, Philip Carvalho, Mark J. Lim and Kenneth J. Rothschild

A novel 3D imaging method to establish baseline amyloid‐beta plaque load and analyze compound efficacy in pre‐clinical Alzheimer’s disease animal models

December 24, 2023 • Ferron, G., Linehan, S. T., Ragan, T., Elk, K. J., Garceau, D., & Sasner, M. (2023). In Alzheimer’s & Dementia (Vol. 19, Issue S10). Wiley. • Published Abstract

Evaluation of antibody-based single cell type imaging techniques coupled to multiplexed imaging of N-glycans and collagen peptides by matrix-assisted laser desorption/ionization mass spectrometry imaging

October 16, 2023 • Dunne, J., Griner, J., Romeo, M., Macdonald, J., Krieg, C., Lim, M., Yagnik, G., Rothschild, K. J., Drake, R. R., Mehta, A. S., & Angel, P. M. (2023). In Analytical and Bioanalytical Chemistry (Vol. 415, Issue 28, pp. 7011–7024). Springer Science and Business Media LLC. • Multiomic, Multimodal techniques

Towards Single-Cell MALDI HiPLEX-IHC: Multiplexed, Multiomic and Multimodal Imaging of Targeted Intact Proteins and Untargeted Metabolites

September 17, 2023 • HUPO 2023 • Mark Lim, Gargey Yagnik, Zhi Wan, Jonathan Bell, Joshua Fischer, Ethan Yang, Katherine A. Stumpo, Kenneth J. Rothschild

MALDI HiPLEX-IHC: Highly Multiplex & Multiomic Tissue Imaging with Photocleavable Mass-Tagged Probes

June 5, 2022 • ASMS 2022 • Gargey B. Yagnik; Ziying Liu; Zhi Wan; Kenneth J. Rothschild, Mark J. Lim