Publications - AmberGen

Publications and Posters

A Multiomic and Highly Multiplex Method of Imaging Metabolites, Targeted Proteins and Targeted Transcripts on the Same Lung Cancer Tissue Microarray Using Novel Mass-Tagged Affinity Probes

May 29, 2026 • EACR 2025 • Leonardo G. Dettori, Gargey Yagnik, Jonathan Bell, Zhi Wan, Philip Carvalho, Andrew Yatsuhashi, Nisshanthini Durairaju, Kenneth J. Rothschild, and Mark J. Lim

How can MSI enhance our understanding of ASO distribution?

January 1, 2025 • van der Vloet, L., Hilaire, P. B. S., Bouillod, C., Isin, E. M., Heeren, R. M. A., & Vandenbosch, M. (2025). In Drug Discovery Today ...

A novel 3D imaging method to establish baseline amyloid‐beta plaque load and analyze compound efficacy in pre‐clinical Alzheimer’s disease animal models

December 24, 2023 • Ferron, G., Linehan, S. T., Ragan, T., Elk, K. J., Garceau, D., & Sasner, M. (2023). In Alzheimer’s & Dementia (Vol. 19, Issue S10). Wiley. • Published Abstract

Lipidomic Phenotyping Of Human Small Intestinal Organoids Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

December 7, 2023 • Duivenvoorden, A. A. M., Claes, B. S. R., van der Vloet, L., Lubbers, T., Glunde, K., Olde Damink, S. W. M., Heeren, R. M. A., & Lenaerts, K. (2023). In Analytical Chemistry (Vol. 95, Issue 50, pp. 18443–18450). American Chemical Society (ACS). • Multiomic, Organoids, Lipids, Proteins

A Guide to MALDI Imaging Mass Spectrometry for Tissues

October 25, 2023 • Jessica L. Moore, Georgia Charkoftaki. Journal of Proteome Research 2023, 22 (11) , 3401-3417. • Review Article

Combination of Multimodal Single Cell Imaging Methods with Multiplexed Enzyme-based MALDI-Mass Spectrometry Imaging for Translational Studies

October 23, 2023 • IMSIS 2023 • Jaclyn B. Dunne, Jake Griner, Martin Romeo, Carsten Krieg, Mark Lim, Gargey Yagnik Anand S. Mehta, Richard R. Drake, Peggi M. Angel

Evaluation of antibody-based single cell type imaging techniques coupled to multiplexed imaging of N-glycans and collagen peptides by matrix-assisted laser desorption/ionization mass spectrometry imaging

October 16, 2023 • Dunne, J., Griner, J., Romeo, M., Macdonald, J., Krieg, C., Lim, M., Yagnik, G., Rothschild, K. J., Drake, R. R., Mehta, A. S., & Angel, P. M. (2023). In Analytical and Bioanalytical Chemistry (Vol. 415, Issue 28, pp. 7011–7024). Springer Science and Business Media LLC. • Multiomic, Multimodal techniques

Towards Single-Cell MALDI HiPLEX-IHC: Multiplexed, Multiomic and Multimodal Imaging of Targeted Intact Proteins and Untargeted Metabolites

September 17, 2023 • HUPO 2023 • Mark Lim, Gargey Yagnik, Zhi Wan, Jonathan Bell, Joshua Fischer, Ethan Yang, Katherine A. Stumpo, Kenneth J. Rothschild

Gel-assisted mass spectrometry imaging

June 3, 2023 • Chan, Y. H., Pathmasiri, K. C., Pierre-Jacques, D., Cologna, S. M., & Gao, R. (2023). Cold Spring Harbor Laboratory. • Multiomic and Multimodal techniques

MALDI HiPLEX-IHC: multiomic and multimodal imaging of targeted intact proteins in tissues

May 1, 2023 • Lim, M. J., Yagnik, G., Henkel, C., Frost, S. F., Bien, T., & Rothschild, K. J. (2023). In Frontiers in Chemistry (Vol. 11). Frontiers Media SA. • Multiomic and Multimodal techniques

MALDI-IHC-Guided In-Depth Spatial Proteomics: Targeted and Untargeted MSI Combined

January 13, 2023 • Claes, B. S. R., Krestensen, K. K., Yagnik, G., Grgic, A., Kuik, C., Lim, M. J., Rothschild, K. J., Vandenbosch, M., & Heeren, R. M. A. (2023). In Analytical Chemistry (Vol. 95, Issue 4, pp. 2329–2338). American Chemical Society (ACS). • Multimodal, proteins, lipids

MALDI-IHC-Guided In-Depth Spatial Proteomics

January 1, 2023 • B.S.R. Claes, K. K. Krestensen, G. Yagnik, A Grgic, C. Kuik, M.J. Lim , K.J. Rothschild, M. Vandenbosch, R.M.A. Heeren

MALDI HiPLEX-IHC: Highly Multiplex & Multiomic Tissue Imaging with Photocleavable Mass-Tagged Probes

June 5, 2022 • ASMS 2022 • Gargey B. Yagnik; Ziying Liu; Zhi Wan; Kenneth J. Rothschild, Mark J. Lim