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Publications and Posters

A Multiomic and Highly Multiplex Method of Imaging Metabolites, Targeted Proteins and Targeted Transcripts on the Same Lung Cancer Tissue Microarray Using Novel Mass-Tagged Affinity Probes
May 29, 2026  •  EACR 2025 • Leonardo G. Dettori, Gargey Yagnik, Jonathan Bell, Zhi Wan, Philip Carvalho, Andrew Yatsuhashi, Nisshanthini Durairaju, Kenneth J. Rothschild, and Mark J. Lim
Exploring the Aβ plaque microenvironment in Alzheimer’s disease model mice by multimodal lipid-protein-histology imaging on a benchtop mass spectrometer
February 5, 2025  •  Müller, E., Enzlein, T., Niemeyer, D., von Ammon, L., Stumpo, K., Biber, K., Klein, C., & Hopf, C. (2025). Pharmaceuticals (Basel, Switzerland), 18(2), 252.
Sequential MALDI-HiPLEX-IHC and Untargeted Spatial Proteomics Mass Spectrometry Imaging to Detect Proteomic Alterations Associated with Tumour Infiltrating Lymphocytes
January 3, 2025  •  Bindi, G., Monza, N., de Oliveira, G. S., Denti, V., Fatahian, F., Seyed-Golestan, S.-M. J., L’Imperio, V., Pagni, F., & Smith, A. (2025). In Journal ...
How can MSI enhance our understanding of ASO distribution?
January 1, 2025  •  van der Vloet, L., Hilaire, P. B. S., Bouillod, C., Isin, E. M., Heeren, R. M. A., & Vandenbosch, M. (2025).   In Drug Discovery Today ...
Multiplexed and Multiomic Mass Spectrometry Imaging of MALDI-IHC Photocleavable Mass Tag Tissue Probes, N-Glycomics, and the Extracellular Matrisome from FFPE Tissue Sections
December 24, 2024  •  Taylor, H. B., Dunne, J. B., Lim, M. J., Yagnik, G., Rothschild, K. J., Mehta, A., Drake, R. R., & Angel, P. M. (2024). In Methods in Molecular Biology (pp. 305–332). Springer US. • Multiomic and Multimodal techniques
MALDI-IHC high-plex protein biomarker imaging for fast, non-iterative identification of lung carcinoma subtype
November 13, 2024  •  AACR 2024 • Catherine A. Kita, Leonardo G. Dettori, Kristina Schwamborn, Gargey Yagnik, Kenneth J. Rothschild, Mark J. Lim
Single Cell MALDI-MSI Analysis of Lipids and Proteins within a Replicative Senescence Fibroblast Model
October 30, 2024  •  Sekera, E. R., Rosas, L., Holbrook, J. H., Angeles-Lopez, Q. D., Khaliullin, T., Rojas, M., Mora, A. L., & Hummon, A. B. (2024). In Journal of the American Society for Mass Spectrometry. American Chemical Society (ACS). • Multiomic, Lipids, Proteins, Single-Cell
Targeting ferroptosis with the lipoxygenase inhibitor PTC-041 as a therapeutic strategy for the treatment of Parkinson’s disease
September 18, 2024  •  Minnella, A., McCusker, K. P., Amagata, A., Trias, B., Weetall, M., Latham, J. C., O’Neill, S., Wyse, R. K., Klein, M. B., & Trimmer, J. K. (2024). In H. Nakano (Ed.), PLOS ONE (Vol. 19, Issue 9, p. e0309893). Public Library of Science (PLoS). • Drug study incorporating MALDI-IHC, Pharma
MALDI Imaging applications on a new benchtop MALDI axial TOF instrument
September 9, 2024  •  IMSIS 2024 • Oetjen, Janina, Wendik, Björn, Henkel, Corinna, Kiss, Andras, Nordmann, Christoph, Böhm, Sebastian, Haase, Andreas, Kobarg, Jan Hendrik, Boskamp, Tobias, Schweiger Hufnagel, Ulrike, ...
Mass spectrometry imaging for spatially resolved multi-omics molecular mapping
July 17, 2024  •  Zhang, H., Lu, K.H., Ebbini, M. et al. npj Imaging 2, 20 (2024). • Multiomic, Review Article
Gel-assisted mass spectrometry imaging enables sub-micrometer spatial lipidomics
June 12, 2024  •  Chan, Y. H., Pathmasiri, K. C., Pierre-Jacques, D., Hibbard, M. C., Tao, N., Fischer, J. L., Yang, E., Cologna, S. M., & Gao, R. (2024). In Nature Communications (Vol. 15, Issue 1). Springer Science and Business Media LLC. • Multiomic, GAMSI, Expansion-Microscopy, Lipids, Proteins
Multimodal Omics Imaging of Human Brain Using MALDI HiPLEX-IHC
June 2, 2024  •  ASMS 2024 • Yumiko Toyama, Takashi Nirasawa, Shigeo Murayama, Yuko Saito, Maho Morishima, Masaya Ikegawa
Multiplex and multiomic MS imaging of drugs, metabolites, and immunolabeled pathogenic protein markers within a single tissue section
June 2, 2024  •  ASMS 2024 • Prem Shankar; Reina N Paez; David Beaver; Bandana Bera; Brendan Prideaux
Combining Drug and Targeted Protein Imaging to Uncover Molecular Changes Associated with Cancer Treatment
June 2, 2024  •  ASMS 2024 • Erin H. Seeley, Catherine A. Kita, Gargey Yagnik, Kenneth J. Rothschild, Mark J. Lim, Rahul A. Sheth
MALDI-ICC and SpaceM on PBMCs Spiked with Cancer Cells for Highly Multiplexed, Multiomic and Multimodal Single-Cell Profiling
June 2, 2024  •  ASMS 2024 • Ziying Liu, Gargey Yagnik, Sharath K. Menon, Shawn Owens, Leonardo G. Dettori, Philip Carvalho, Kenneth J. Rothschild, Theodore Alexandrov, and Mark J. ...
Cyclic MALDI-IHC for Successive High-plex and Multimodal Imaging of Tissues and Tissue Microarrays
June 2, 2024  •  ASMS 2024 • Leonardo G. Dettori, Gargey Yagnik, Philip Carvalho, Mark J. Lim and Kenneth J. Rothschild
Multimodal Mass Spectrometry Imaging of an Osteosarcoma Multicellular Tumour Spheroid Model to Investigate Drug-Induced Response
May 29, 2024  •  Pearce, S.M.; Cross, N.A.; Smith, D.P.; Clench, M.R.; Flint, L.E.; Hamm, G.; Goodwin, R.; Langridge, J.I.; Claude, E.; Cole, L.M. Metabolites 2024, 14, 315. • Drug study, Multiomic, Multimodal, Tumor Spheroids
Real-time glioblastoma tumor microenvironment assessment by SpiderMass for improved patient management
April 16, 2024  •  Zirem, Y., Ledoux, L., Roussel, L., Maurage, C. A., Tirilly, P., Le Rhun, É., Meresse, B., Yagnik, G., Lim, M. J., Rothschild, K. J., Duhamel, M., Salzet, M., & Fournier, I. (2024). In Cell Reports Medicine (Vol. 5, Issue 4, p. 101482). Elsevier BV. • MALDI-IHC was orthogonal verification tech
Abstract 7088: MALDI-IHC high-plex protein biomarker imaging for fast, non-iterative identification of lung carcinoma subtypes
March 15, 2024  •  Kita, C. A., Schwamborn, K., Yagnik, G., Rothschild, K. J., & Lim, M. J. (2024). In Cancer Research (Vol. 84, Issue 6_Supplement, pp. 7088–7088). American Association for Cancer Research (AACR). • Clinical Translation, Published Abstract
Molecular analysis of the extracellular microenvironment: from form to function
March 1, 2024  •  Macdonald, J. K., Mehta, A. S., Drake, R. R., & Angel, P. M. (2024). In FEBS Letters (Vol. 598, Issue 6, pp. 602–620). Wiley. • Multiomics, Tools to be used for studying tumor ECM inc. MALDI-IHC
Advancing rare cancer research by MALDI mass spectrometry imaging: Applications, challenges, and future perspectives in sarcoma
February 25, 2024  •  Stillger, M. N., Li, M. J., Hönscheid, P., von Neubeck, C., & Föll, M. C. (2024). In PROTEOMICS (Vol. 24, Issues 12–13). Wiley. • Multiomic and Multimodal techniques
Quantitative mass spectrometry imaging: therapeutics & biomolecules
January 22, 2024  •  Holbrook, J. H., Kemper, G. E., & Hummon, A. B. (2024). In Chemical Communications (Vol. 60, Issue 16, pp. 2137–2151). Royal Society of Chemistry (RSC). • Review Article
Technology Spotlight: Advances in Proteomic Technologies and Their Applications in Hematology
January 17, 2024  •  Mangalaparthi, K. K., & Pandey, A. (2024). In The Hematologist (Vol. 21, Issue 1). American Society of Hematology. • Review Article
Utilizing multimodal mass spectrometry imaging for profiling immune cell composition and N-glycosylation across colorectal carcinoma disease progression
January 10, 2024  •  Young, L. E. A., Nietert, P. J., Stubler, R., Kittrell, C. G., Grimsley, G., Lewin, D. N., Mehta, A. S., Hajar, C., Wang, K., O’Quinn, E. C., Angel, P. M., Wallace, K., & Drake, R. R. (2024). In Frontiers in Pharmacology (Vol. 14). Frontiers Media SA. • Multiomic, Multimodal
A novel 3D imaging method to establish baseline amyloid‐beta plaque load and analyze compound efficacy in pre‐clinical Alzheimer’s disease animal models
December 24, 2023  •  Ferron, G., Linehan, S. T., Ragan, T., Elk, K. J., Garceau, D., & Sasner, M. (2023). In Alzheimer’s & Dementia (Vol. 19, Issue S10). Wiley. • Published Abstract
The journey towards clinical adoption of MALDI-MS-based imaging proteomics: from current challenges to future expectations
December 23, 2023  •  Piga, I., Magni, F., & Smith, A. (2024). In FEBS Letters (Vol. 598, Issue 6, pp. 621–634). Wiley. • Clinical Translation, Review Article
Deep MALDI-MS Spatial ‘Omics guided by Quantum Cascade Laser Mid-infrared Imaging Microscopy
December 14, 2023  •  Gruber, L., Schmidt, S., Enzlein, T., Vo, H. G., Cairns, J. L., Ucal, Y., Keller, F., Abu Sammour, D., Rudolf, R., Eckhardt, M., Iakab, S. A., Bindila, L., & Hopf, C. (2023). Cold Spring Harbor Laboratory. • Multiomic and Multimodal techniques
Lipidomic Phenotyping Of Human Small Intestinal Organoids Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging
December 7, 2023  •  Duivenvoorden, A. A. M., Claes, B. S. R., van der Vloet, L., Lubbers, T., Glunde, K., Olde Damink, S. W. M., Heeren, R. M. A., & Lenaerts, K. (2023). In Analytical Chemistry (Vol. 95, Issue 50, pp. 18443–18450). American Chemical Society (ACS). • Multiomic, Organoids, Lipids, Proteins
A Guide to MALDI Imaging Mass Spectrometry for Tissues
October 25, 2023  •  Jessica L. Moore, Georgia Charkoftaki. Journal of Proteome Research 2023, 22 (11) , 3401-3417. • Review Article
Combination of Multimodal Single Cell Imaging Methods with Multiplexed Enzyme-based MALDI-Mass Spectrometry Imaging for Translational Studies
October 23, 2023  •  IMSIS 2023 • Jaclyn B. Dunne, Jake Griner, Martin Romeo, Carsten Krieg, Mark Lim, Gargey Yagnik Anand S. Mehta, Richard R. Drake, Peggi M. Angel
Evaluation of antibody-based single cell type imaging techniques coupled to multiplexed imaging of N-glycans and collagen peptides by matrix-assisted laser desorption/ionization mass spectrometry imaging
October 16, 2023  •  Dunne, J., Griner, J., Romeo, M., Macdonald, J., Krieg, C., Lim, M., Yagnik, G., Rothschild, K. J., Drake, R. R., Mehta, A. S., & Angel, P. M. (2023). In Analytical and Bioanalytical Chemistry (Vol. 415, Issue 28, pp. 7011–7024). Springer Science and Business Media LLC. • Multiomic, Multimodal techniques
Towards Single-Cell MALDI HiPLEX-IHC: Multiplexed, Multiomic and Multimodal Imaging of Targeted Intact Proteins and Untargeted Metabolites
September 17, 2023  •  HUPO 2023 • Mark Lim, Gargey Yagnik, Zhi Wan, Jonathan Bell, Joshua Fischer, Ethan Yang, Katherine A. Stumpo, Kenneth J. Rothschild
MALDI HiPLEX-IHC Imaging of FFPE Human Kidney Tissue at 5 µm utilizing microGRID on timsTOF fleX MALDI-2
June 4, 2023  •  ASMS 2023 • Connor West, Joshua Fischer, Corrina Henkel, Sumankalai Ramachandran, Azad Eshghi, Gargey Yagnik, Mark Lim
Gel-assisted mass spectrometry imaging
June 3, 2023  •  Chan, Y. H., Pathmasiri, K. C., Pierre-Jacques, D., Cologna, S. M., & Gao, R. (2023). Cold Spring Harbor Laboratory. • Multiomic and Multimodal techniques
MALDI HiPLEX-IHC: multiomic and multimodal imaging of targeted intact proteins in tissues
May 1, 2023  •  Lim, M. J., Yagnik, G., Henkel, C., Frost, S. F., Bien, T., & Rothschild, K. J. (2023). In Frontiers in Chemistry (Vol. 11). Frontiers Media SA. • Multiomic and Multimodal techniques
MALDI-IHC-Guided In-Depth Spatial Proteomics: Targeted and Untargeted MSI Combined
January 13, 2023  •  Claes, B. S. R., Krestensen, K. K., Yagnik, G., Grgic, A., Kuik, C., Lim, M. J., Rothschild, K. J., Vandenbosch, M., & Heeren, R. M. A. (2023). In Analytical Chemistry (Vol. 95, Issue 4, pp. 2329–2338). American Chemical Society (ACS). • Multimodal, proteins, lipids
MALDI-IHC-Guided In-Depth Spatial Proteomics
January 1, 2023  •  B.S.R. Claes, K. K. Krestensen, G. Yagnik, A Grgic, C. Kuik, M.J. Lim , K.J. Rothschild, M. Vandenbosch, R.M.A. Heeren
Mass spectrometry imaging in gynecological cancers: the best is yet to come
December 19, 2022  •  Pietkiewicz, D., Plewa, S., Zaborowski, M., Garrett, T. J., Matuszewska, E., Kokot, Z. J., & Matysiak, J. (2022). In Cancer Cell International (Vol. 22, Issue 1). Springer Science and Business Media LLC. • Multiomic and Multimodal techniques
MALDI HiPLEX-IHC: Highly Multiplex & Multiomic Tissue Imaging with Photocleavable Mass-Tagged Probes
June 5, 2022  •  ASMS 2022 • Gargey B. Yagnik; Ziying Liu; Zhi Wan; Kenneth J. Rothschild, Mark J. Lim
Highly Multiplexed Immunohistochemical MALDI-MS Imaging of Biomarkers in Tissues
February 25, 2021  •  Yagnik, G., Liu, Z., Rothschild, K. J., & Lim, M. J. (2021). In Journal of the American Society for Mass Spectrometry (Vol. 32, Issue 4, pp. 977–988). American Chemical Society (ACS). • MALDI-IHC overview